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KMID : 0356920130640050439
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Korean Journal of Anesthesiology
2013 Volume.64 No. 5 p.439 ~ p.442
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Effect of stellate ganglion block on laryngopharyngeal reflux disease
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Chung Ji-Won
Chun Hye-Jung
Ahn Ki-Ryang
Kim Chun-Sook
Kang Kyu-Sik
Yoo Sie-Hyeon
Chung Jin-Hun
Kim Nan-Seol
Seo Yong-Han
Gong Hyung-Youn
Lee Yong-Man
Lee Mi-Soon
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Abstract
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Background: Laryngopharyngeal reflux (LPR) disease has many symptoms such as globus pharyngeus, excessive throat clearing and hoarseness. The aim of this study was to investigate the effect of stellate ganglion block (SGB) in addition to proton pump inhibitors (PPI) on LPR.
Methods: Fifty patients complaining of more than 3 typical LPR symptoms for over 3 months were enrolled in the study. The P group took PPI for 8 weeks. The SP group took PPI and interwent a series of 8 SGB procedure once a week during the period of treatment. The blocks were performed one at a time unilaterally on the right and left stellate ganglions by injecting 1% mepivacaine 6 ml. We evaluated the reflux symptom index (RSI) before treatment and following 4 weeks and 8 weeks of treatment in both groups.
Results: After 4 weeks of treatment, the RSI of the P group decreased, but not significantly, to 16.6 ± 6.8 compared with the baseline value of 19.2 ± 2.7 (P = 0.093), whereas the RSI of the SP group decreased significantly to 9.8 ± 3.3 compared with the baseline value of 19.0 ± 4.7 (P = 0.000). After 8 weeks of treatment, the RSI of the P group decreased significantly to 13.7 ± 6.7 (P = 0.001) and the RSI of the SP group also decreased significantly to 7.7 ± 3.4 (P = 0.000). There were significant differences in the RSI between the two groups after 4 weeks (P = 0.000) and 8 weeks (P = 0.001) of treatment.
Conclusions: The symptoms of LPR improved earlier when PPI therapy was combined with SGB compared with PPI therapy alone.
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KEYWORD
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Laryngopharyngeal reflux, Proton pump inhibitors, Stellate ganglion block
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